Noise Propagation in Synthetic Gene Circuits for Metabolic Control
نویسندگان
چکیده
منابع مشابه
Noise propagation in synthetic gene circuits for metabolic control.
Dynamic control of enzyme expression can be an effective strategy to engineer robust metabolic pathways. It allows a synthetic pathway to self-regulate in response to changes in bioreactor conditions or the metabolic state of the host. The implementation of this regulatory strategy requires gene circuits that couple metabolic signals with the genetic machinery, which is known to be noisy and on...
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Barbara Jusiak1,2, Ramiz Daniel1,3, Fahim Farzadfard2–5, Lior Nissim1,3, Oliver Purcell2,3, Jacob Rubens1,3,5, and Timothy K. Lu1–6 1Massachusetts Institute of Technology, Research Laboratory of Electronics, Cambridge, MA 02139, USA 2Massachusetts Institute of Technology, Department of Biological Engineering, Cambridge, MA 02139, USA 3Massachusetts Institute of Technology, Synthetic Biology Cen...
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Accurately predicting noise propagation in gene networks is crucial for understanding signal fidelity in natural networks and designing noise-tolerant gene circuits. To quantify how noise propagates through gene networks, we measured expression correlations between genes in single cells. We found that noise in a gene was determined by its intrinsic fluctuations, transmitted noise from upstream ...
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ژورنال
عنوان ژورنال: ACS Synthetic Biology
سال: 2014
ISSN: 2161-5063,2161-5063
DOI: 10.1021/sb400126a